Ipamorelin 5mg

Overview

Ipamorelin is a laboratory-synthesized pentapeptide commonly employed in research as a highly selective agonist of the growth hormone secretagogue receptor (GHSR-1a), also referred to as the ghrelin receptor. In controlled experimental environments, ipamorelin is used as a research tool to examine ghrelin-receptor pharmacology, ligand specificity, and intracellular signaling pathways associated with G protein–coupled receptor (GPCR) activation.

Due to its reported receptor selectivity in preclinical systems, ipamorelin is frequently incorporated into structure–activity relationship (SAR) studies. Its use allows investigators to evaluate GHSR-specific signaling while minimizing confounding activity observed with broader, less selective growth hormone secretagogues in both cell-based assays and animal research models.

Biochemical Characteristics

Reference Source: Public chemical and peptide databases

Amino Acid Sequence: Aib-His-D-2Nal-D-Phe-Lys

Molecular Formula: C₃₈H₄₉N₉O₅

Molecular Weight: 711.87 g/mol

PubChem CID: 9831659

CAS Registry Number: 170851-70-4

Ipamorelin contains non-proteinogenic amino acid residues, a feature commonly incorporated into peptide design to improve receptor selectivity and resistance to enzymatic degradation in experimental systems. The peptide is typically produced using solid-phase peptide synthesis and characterized using standard analytical techniques.

Research Applications

Ipamorelin is supplied exclusively for laboratory research use and has been utilized in preclinical and in-vitro investigations involving:

• GHSR-1a binding affinity and receptor selectivity assays
• Second-messenger signaling studies, including calcium mobilization and cAMP-associated readouts
• Ligand–receptor SAR analyses and comparative studies with other ghrelin mimetics
• Endocrine-axis modeling in animal research as a receptor-selective pharmacological probe
• Experimental evaluation of gastrointestinal motility signaling, pancreatic islet signaling, and metabolic pathway markers in controlled laboratory settings
  

All applications are strictly limited to non-clinical experimental research.

Pathway & Mechanistic Context

In experimental models, ipamorelin is used to investigate signaling initiated through GHSR-1a activation. Receptor engagement has been associated with intracellular calcium mobilization and modulation of adenylate cyclase activity, leading to downstream phosphorylation events and transcription-related signaling responses.

Both in-vitro and animal-based studies have employed ipamorelin to assess how selective GHSR activation influences second-messenger dynamics and pathway coupling across Gq- and Gs-linked signaling mechanisms. Its selectivity makes ipamorelin a useful comparator compound for distinguishing GHSR-mediated signaling from broader secretagogue effects observed with less selective ligands.

Summary of Preclinical Research Contexts

Glucocorticoid-Related Signaling Models

Rodent studies have examined ipamorelin in experimental systems modeling glucocorticoid-associated changes in bone, muscle, and nitrogen metabolism. Reported laboratory endpoints include markers of osteoblastic activity, bone formation indices, and nitrogen balance parameters under controlled research conditions.

Pancreatic Islet & Metabolic Signaling

In isolated pancreas preparations and diabetic rodent models, ipamorelin has been evaluated for experimental effects related to insulin-release mechanisms. These studies focus on calcium-dependent signaling processes within pancreatic islet cells using defined experimental designs.

Gastrointestinal Motility Models

Preclinical models of postoperative ileus have been used to explore ghrelin-receptor–mediated signaling related to gastrointestinal motility. Experimental readouts include gastric emptying rates and intestinal transit distribution assessed using radiolabeled markers.

Molecular Imaging Research

Owing to its receptor selectivity and synthetic flexibility, ipamorelin has also been explored as a scaffold for peptidomimetic derivatives in molecular imaging research. In-vitro feasibility studies have examined radiolabeled analogues for ghrelin receptor visualization in experimental imaging system development.

Source: PubMed

Formulation & Analytical Verification

Ipamorelin is supplied as a synthetic peptide intended for laboratory handling and research workflows. Molecular identity and purity are verified using high-performance liquid chromatography (HPLC) and mass spectrometry (MS). Batch-specific analytical documentation is provided to support reproducibility and consistency across experimental applications.

Research Use Only (RUO) Notice

All products available on this website are provided exclusively for in-vitro laboratory research purposes. In-vitro studies are conducted outside of living organisms under controlled experimental conditions.

These materials are not drugs, medicines, or therapeutic agents and have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) for the diagnosis, treatment, prevention, or cure of any disease or medical condition.

Any form of administration or introduction into humans or animals is strictly prohibited by law.

All products are prepared using a lyophilization (freeze-drying) method designed to preserve peptide integrity during transit. When maintained under proper conditions prior to reconstitution, lyophilized peptides remain stable for shipping for approximately 3–4 months.

After reconstitution with bacteriostatic water, peptides must be stored under refrigeration to retain stability. Once mixed, reconstituted peptides remain stable for up to 30 days when kept refrigerated.

The Lyophilization Process

Lyophilization, sometimes referred to as cryodesiccation, is a controlled dehydration technique in which peptides are frozen and then exposed to reduced atmospheric pressure. This process allows ice to transition directly into vapor, removing moisture without damaging molecular structure. The result is a dry, porous, white powder—known as a lyophilized peptide—that can be stored at room temperature until reconstitution is required.

Storage & Handling Guidelines

Upon receipt, peptides should be stored in a cool environment and protected from light exposure. For short-term use—ranging from immediate application to several weeks or months—refrigeration below 4°C (39°F) is generally sufficient. Lyophilized peptides also exhibit short-term stability at ambient temperatures, making room-temperature storage acceptable when use is planned within a limited timeframe.

For long-term preservation extending several months to years, peptides should be stored in an ultra-low-temperature freezer at approximately −80°C (−112°F). Deep freezing is the preferred method for maintaining peptide stability and structural integrity over extended storage periods.