GHK-Cu 75mg

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GHK-Cu (Copper Tripeptide-1) — Full Product Page (Detailed Overview Version)

Product Title:
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) — Naturally Occurring Tripeptide–Metal Complex Research Compound

Short Description:
A naturally occurring tripeptide–metal complex identified in plasma, saliva, and extracellular matrix environments, investigated in controlled laboratory research for peptide–metal interaction modeling, copper homeostasis pathway dynamics, extracellular matrix regulation research, and copper-dependent signaling mechanism investigation. ≥99% Purity, HPLC-Verified. Third-Party CoA Included. For in-vitro laboratory research use only.

Full Product Description:

Overview

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring tripeptide–metal complex identified in plasma, saliva, and extracellular matrix environments. The peptide demonstrates strong affinity for divalent copper (Cu²⁺) and has been extensively examined in controlled laboratory research for its involvement in cellular communication pathway dynamics, extracellular matrix regulation mechanisms, and copper homeostasis investigation.

Scientific investigation of GHK-Cu is strictly limited to in-vitro systems and in-vivo animal research models, where it is utilized as a molecular tool to explore peptide–metal interactions and copper-dependent signaling mechanisms under defined experimental conditions. No references herein imply clinical, cosmetic, or therapeutic use of any kind.

Biochemical Characteristics

• Peptide Sequence: Gly-His-Lys (Cu²⁺)
• Molecular Formula: C₁₄H₂₃CuN₆O₄
• Molecular Weight: 401.91 g/mol
• PubChem CID: 73587
• CAS Number: 89030-95-5

GHK-Cu is a low-molecular-weight copper-binding tripeptide in which coordination of Cu²⁺ occurs through the histidine imidazole ring and terminal amine groups. This chelation stabilizes copper in a controlled redox state, reducing nonspecific oxidative activity and enabling reproducible experimentation in controlled laboratory systems.

Biochemical studies indicate that the GHK-Cu complex interacts with extracellular matrix components, transcriptional regulators, and membrane-associated proteins in experimental systems. These properties make it a useful research compound for investigating copper-dependent enzymatic processes, redox-regulated signaling pathways, and matrix remodeling dynamics under controlled experimental conditions.

Research Applications

GHK-Cu is widely employed in controlled laboratory research examining the following experimental areas:

Extracellular Matrix & Fibroblast Research
Fibroblast migration endpoint dynamics and extracellular matrix synthesis pathway investigation in controlled cell-based research systems.

Endothelial Cell & Angiogenesis Research
Endothelial cell signaling pathway dynamics and angiogenesis-associated molecular marker investigation in defined laboratory experimental settings.

Immune Cell & Inflammatory Mediator Research
Immune-cell recruitment pathway dynamics and inflammatory mediator modulation endpoint investigation in controlled preclinical research models.

Neuronal Signaling Research
Neuronal survival pathway dynamics and regeneration-associated signaling pathway endpoint investigation in controlled cell-based and animal research systems.

Experimental model systems include dermal fibroblast cultures, endothelial assay platforms, neuronal cell research systems, and controlled animal studies designed to evaluate molecular and transcriptional response endpoints.

Additional research applications include:

• Oxidative stress modulation pathway investigation
• Antimicrobial peptide interaction research
• Stem cell–associated signaling marker endpoint analysis
• Gene-expression response profiling related to tissue remodeling dynamics under defined experimental conditions

Pathway & Mechanistic Context

Mechanistic investigations document GHK-Cu involvement across multiple biochemical signaling pathways in controlled experimental systems, including:

• Integrin-mediated signaling pathway dynamics and downstream cascade activity
• Transforming growth factor-β (TGF-β)–associated regulatory pathway research
• Pro-inflammatory cytokine expression suppression pathway endpoint investigation
• Antioxidant response element activation dynamics in controlled research models

Gene-expression analyses further document that GHK-Cu modulates transcriptional networks associated with:

• Cellular migration pathway dynamics and directional motility signaling
• Extracellular matrix turnover and remodeling mechanism research
• Neuronal maintenance signaling pathway endpoint investigation
• Redox balance regulation and antioxidant response network dynamics

Copper sequestration by the peptide in experimental systems appears to limit metal-catalyzed oxidative stress activity, thereby influencing downstream signaling behavior under defined experimental conditions.

Preclinical Research Summary

Preclinical research involving GHK-Cu includes in-vitro fibroblast and keratinocyte studies, neuronal regeneration assay systems, antimicrobial interaction research models, and multiple controlled animal models of tissue injury and inflammatory response pathway dynamics.

Reported laboratory observations from controlled experimental systems include:

• Altered cellular migration dynamic endpoints
• Changes in extracellular matrix deposition pattern markers
• Inflammatory mediator modulation pathway activity
• Gene-expression profile shifts associated with stress-response and regenerative signaling pathway dynamics

All findings are presented strictly as controlled experimental observations without implication of clinical, cosmetic, or therapeutic outcomes of any kind.

Form & Analytical Testing

GHK-Cu is supplied as a synthetic research-grade peptide–metal complex for controlled laboratory workflows. Identity and purity are confirmed using:

• HPLC — purity profiling and lot consistency verification
• Mass Spectrometry (MS) — molecular identity confirmation

Batch-specific analytical documentation is provided where applicable to support research reproducibility across laboratory workflows.

Purity & Quality

• ≥99% Purity — HPLC Verified
• Independently tested by accredited third-party laboratory
• Certificate of Analysis (CoA) available for every batch

Research Use Only (RUO) Notice

All products are furnished strictly for in-vitro laboratory research use only. These materials are not medicines or drugs and have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease or medical condition. Bodily introduction of any kind into humans or animals is strictly prohibited. Not for human, medical, diagnostic, or veterinary use.

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GHK-Cu (Copper Tripeptide-1) — Storage & Stability Guidelines

Page/Section Title:
GHK-Cu (Copper Tripeptide-1) — Storage, Stability & Lyophilization Information

Short Introduction:
All P1 Peptides GHK-Cu research compounds are manufactured using a lyophilization (freeze-drying) process to ensure maximum structural integrity and compound stability during transit and storage. The following guidelines are provided to support proper laboratory handling of this research-grade peptide–metal complex material.

Manufacturing Process: Lyophilization

All GHK-Cu research compounds supplied by P1 Peptides are produced using lyophilization — also referred to as cryodesiccation — a specialized dehydration technique widely employed in the manufacture of research-grade synthetic peptide materials.

During this process, peptides are first frozen and then subjected to a reduced-pressure environment, allowing ice to transition directly from solid to vapor phase through sublimation — effectively removing moisture without compromising molecular structure. This yields a dry, porous white solid — commonly referred to as a lyophilized peptide — that preserves full structural integrity of the compound throughout the handling and storage period.

In its lyophilized form, GHK-Cu research compounds remain stable during shipping for approximately 3–4 months under appropriate conditions prior to reconstitution.

Reconstitution

When research protocols require reconstitution, GHK-Cu is typically prepared using bacteriostatic water under controlled laboratory conditions. Once reconstituted, the peptide solution should be stored under refrigerated conditions to maintain compound stability and structural integrity. Reconstituted solutions generally maintain stability for up to 30 days when kept appropriately refrigerated.

All reconstitution procedures should be carried out in accordance with standard laboratory protocols applicable to synthetic peptide–metal complex research materials.

Recommended Storage Guidelines

The following storage parameters are recommended to maintain compound integrity throughout the research lifecycle:

Short-Term Storage — Unopened Lyophilized Vials

• Upon Receipt — Protect from heat and direct light exposure immediately upon receipt
• Near-Term Use (days to weeks) — Refrigeration below 4°C (39°F) is generally sufficient to maintain compound integrity
• Room Temperature Storage — Lyophilized GHK-Cu typically retains stability at ambient temperature for several weeks, making short-term room-temperature storage acceptable when laboratory use is anticipated within that timeframe prior to reconstitution

Long-Term Storage — Unopened Lyophilized Vials

• Extended Storage (several months or longer) — Storage at ultra-low temperatures is strongly recommended for long-term compound preservation
• Optimal Long-Term Preservation — Freezing at approximately −80°C (−112°F) is considered optimal for preserving peptide–metal complex stability and minimizing degradation over extended storage periods

Post-Reconstitution Storage

• Store reconstituted solutions under refrigeration below 4°C (39°F), away from direct light and heat sources
• Do not freeze reconstituted solutions
• Discard any unused reconstituted material after 30 days or upon observation of cloudiness, discoloration, or particulate matter

Additional Laboratory Guidance

For specific storage requirements applicable to this research compound, researchers should consult the Certificate of Analysis (CoA) provided with each batch, as well as applicable peer-reviewed literature and institutional laboratory protocols governing synthetic peptide–metal complex handling and storage procedures.

Research Use Only (RUO) Notice

All products are furnished strictly for in-vitro laboratory research use only. These materials are not medicines or drugs and have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease or medical condition. Introduction into humans or animals is strictly prohibited. Not for human, medical, diagnostic, or veterinary use.