Overview
Epithalon (also referenced in scientific literature as Epitalon, Epithalone, or Epithalamin) is a synthetic tetrapeptide composed of the amino acid sequence Ala-Glu-Asp-Gly. It is utilized as a laboratory research reagent in experimental models investigating telomere-associated enzymology, peptide–nucleic acid interactions, transcriptional regulation, and circadian-linked molecular signaling pathways.
Published literature includes controlled cell-based experiments and in-vivo animal studies assessing molecular endpoints such as telomerase-associated activity, gene-expression profiles, and pathway-level biomarkers. Research models referenced in the literature include insects, rodents, non-human primates, and standardized cellular systems used to quantify genome-stability metrics and transcriptional responses to short regulatory peptides.
Biochemical Characteristics
- Sequence: Ala-Glu-Asp-Gly
- Molecular Formula: C₁₄H₂₂N₄O₉
- Molecular Weight: 390.349 g/mol
- PubChem CID: 219042
- CAS Number: 307297-39-8
Research Applications
Epithalon is employed in experimental research environments investigating the following scientific areas:
Telomere Biology & Telomerase-Associated Enzymology
Cell-based systems measuring telomerase activity, telomere-length metrics, and genome-integrity endpoints under defined laboratory conditions.
Peptide–DNA Interaction Studies
Experimental models evaluating interactions between short regulatory peptides and gene promoter regions, with subsequent transcriptional analysis and expression profiling.
Transcriptional Regulation & Gene-Expression Profiling
Assays measuring changes in defined molecular targets involved in signaling cascades, extracellular matrix biology, and protein-biogenesis pathways.
Circadian-Linked Molecular Signaling
Studies examining rhythmic transcriptional targets associated with pineal signaling pathways, including AANAT- and pCREB-related signaling models.
Extracellular Matrix & Connective Tissue Research
Fibroblast-based models evaluating matrix-remodeling biomarkers, including MMP2-associated endpoints and connective tissue signaling dynamics.
Oncology-Related Experimental Models
Rodent and transgenic tumor systems assessing tumor-associated molecular and phenotypic endpoints under defined laboratory conditions.
Retinal Research Models
Rodent models assessing retinal structural and electrophysiologic parameters in controlled experimental settings.
Pathway & Mechanistic Context
Mechanistic investigations position Epithalon within several experimentally defined molecular frameworks:
- Telomerase-associated activity and telomere-length outcomes in cell-based systems
- Promoter-interaction models involving CD5, IL-2, MMP2, and Tram1 regulatory regions
- Transcriptional signaling involving AANAT and pCREB pathways
- Genome-stability and enzyme-activity endpoints relevant to telomere-maintenance research
Reported molecular endpoints in published experimental literature include:
- CD5 — immune-lineage promoter modeling
- IL-2 — cytokine-associated transcriptional endpoints
- MMP2 — extracellular matrix remodeling marker
- Tram1 — protein-biogenesis and translocation modeling
- AANAT — circadian and pineal transcriptional regulation
- pCREB — transcriptional signaling mediator
- Telomerase — enzymatic activity endpoint in genome-stability research
Preclinical Research Summary
1. Telomere-Associated & Genome-Integrity Models
Insect and rodent studies evaluating survival curves, biomarker panels, tumor-incidence endpoints, and telomerase-associated activity under defined experimental conditions.
2. Promoter-Interaction & Gene-Expression Modeling
Cell-culture and rodent studies assessing transcriptional modulation via promoter-interaction assays and molecular expression readouts.
3. Fibroblast & Extracellular Matrix Biomarkers
In-vitro and rodent studies measuring fibroblast functional states, MMP2-linked remodeling markers, and apoptosis-related endpoints such as caspase-3 activity.
4. Tumor-Model Endpoints
Rodent and transgenic systems evaluating tumor-development metrics, metastasis-associated observations, and molecular correlates of oncogenic signaling. Circadian-gene frameworks including PER1-associated signaling are also evaluated within experimental oncology paradigms.
5. Pineal-Linked Rhythmic Signaling
Research examining transcriptional targets such as AANAT and pCREB, as well as primate studies assessing daily secretion-rhythm profiles under controlled laboratory conditions.
6. Retinal Experimental Models
Rodent retinal-degeneration models evaluating structural integrity and electrophysiologic measurements under controlled laboratory conditions.
Form & Analytical Characterization
Epithalon is supplied as a synthetic tetrapeptide research material intended for controlled laboratory workflows. Laboratories typically verify peptide identity and assess analytical characteristics using validated peptide-analysis methodologies consistent with internal quality-control protocols.
Registry identifiers and structural data including sequence, molecular formula, molecular weight, PubChem CID, and CAS number are provided to support internal documentation and study design.
Purity & Quality
- ≥99% Purity — HPLC Verified
- Independently tested by accredited third-party laboratory
- Certificate of Analysis (CoA) available for every batch
Research Use Only (RUO) Notice
All products are furnished strictly for in-vitro laboratory research use only. "In-vitro" refers to studies conducted outside of a living organism in controlled laboratory conditions. These materials are not medicines or drugs and have not been evaluated or approved by the U.S. Food and Drug Administration (FDA) to diagnose, treat, cure, or prevent any disease or medical condition. Bodily introduction into humans or animals is strictly prohibited. Not for human, medical, diagnostic, or veterinary use.
